This volume is a collection of essays by various contributors in honor of the late Laurence Berns, Richard Hammond Elliot Tutor Emeritus at St. John's College, Annapolis. The essays address the literary, political, theological, and philosophical themes of his life's work as a scholar, teacher, and constant companion of the "great books.".

Current economic ontology development has failed to confront two important errors associated with historicism. Embracing the linearity of economic value being directly attributed to the labor applied to natural resources taken together with efficiency arguments used to justify monetary policy on both the microlevel (transaction) and macrolevel (global trade), we know these legacies of the scientific method applied to economic systems have left the G-20 paralyzed to deal with structural failings evidenced from banking to business to economic policy. An exploration (...) of the structural modalities that impair our current capacity for adaptation and alternative methods for accounting for value is the basis for this inquiry. Integral accounting is proposed as a more suitable method to transition from scarcity-based market models to abundance-based modes of sustainable engagement. (shrink)

The essays in this collection are all studies in the history of modern philosophy. Together they provide a cross-section of current efforts to reconstruct ...

In this paper I describe the apparent differences between the views of Mizrahi and Seidel on the strength of arguments from expert opinion. I show that most of Seidel's objections rely on an understanding of the words 'expert' and 'opinion' different from those which Mizrahi employs. I also discuss certain inconsistencies found in both papers over the use of these key terms. The paper concludes by noting that Mizrahi is right to suggest that evidence shows expert predictions to be unreliable, (...) but Seidel is correct to observe that this finding should not be used to claim that expert opinion in general is not to be trusted. (shrink)

The purpose of this paper is twofold: to give a good account of the argument from ignorance, with a presumptive argumentation scheme, and to raise issues on the work of Walton, the nature of abduction and the concept of epistemic closure. First, I offer a brief disambiguation of how the terms 'argument from ignorance' and 'argumentum ad ignorantiam' are used. Second, I show how attempts to embellish this form of reasoning by Douglas Walton and A.J. Kreider have been unnecessary and (...) unhelpful. Lastly, I offer a full and effective account of the argument from ignorance and discuss the lessons of the analysis.Le but de cet article est double: donner un bon compte rendu de l'argument par l'ignorance, avec un schème d'argumentation présomptif, et soulever des questions sur certains aspects de l’œuvre de Walton, la nature des raisonnements abductifs et le concept de fermeture épistémique. Premièrement, j'offre une brève désambiguïsation de la façon dont les termes «argument par l'ignorance» et «argumentum ad ignorantiam» sont utilisés. Deuxièmement, je montre comment les tentatives de Douglas Walton et de A.J. Kreider d'embellir cette forme de raisonnement ont été ni nécessaires et ni utiles. Enfin, j'offre un compte-rendu complet et utile de l'argument par l'ignorance et je discute des leçons de l'analyse. (shrink)

Digital contact tracing, in combination with widespread testing, has been a focal point for many plans to “reopen” economies while containing the spread of Covid‐19. Most digital contact tracing projects in the United States and Europe have prioritized privacy protections in the form of local storage of data on smartphones and the deidentification of information. However, in the prioritization of privacy in this narrow form, there is not sufficient attention given to weighing ethical trade‐offs within the context of a public (...) health pandemic or to the need to evaluate safety and effectiveness of software‐based technology applied to public health. (shrink)

Over the last few years, a new methodology to address the P versus NP problem has been developed, based on searching for borderlines between the nonefficiency of computing models and the presumed efficiency. These borderlines can be seen as frontiers of efficiency, which are crucial in this methodology. “Translating,” in some sense, an efficient solution in a presumably efficient model to an efficient solution in a nonefficient model would give an affirmative answer to problem P versus NP. In the framework (...) of Membrane Computing, the key of this approach is to detect the syntactic or semantic ingredients that are needed to pass from a nonefficient class of membrane systems to a presumably efficient one. This paper deals with tissue P systems with communication rules of type symport/antiport allowing the evolution of the objects triggering the rules. In previous works, frontiers of efficiency were found in these kinds of membrane systems both with division rules and with separation rules. However, since they were not optimal, it is interesting to refine these frontiers. In this work, optimal frontiers of the efficiency are obtained in terms of the total number of objects involved in the communication rules used for that kind of membrane systems. These optimizations could be easier to translate, if possible, to efficient solutions in a nonefficient model. (shrink)

Expression of transgenes in mice, when examined with assays that can distinguish individual cells, is often found to be heterocellular, or variegated. Line‐to‐line variations in expression of a transgene may be due largely to differences in the proportion of cells in which it is expressed. Variegated silencing by centromeric heterochromatin is well described, but other factors may also affect transgene silencing in mice. Tandem arrays of transgenes themselves form heterochromatin, and some cell lineages may tend to silence transgenes because of (...) extensive facultative heterochromatin in their nuclei. The cis‐acting transcriptional control elements within a transgene inhibit silencing, and strainspecific differences in chromatin proteins may strongly influence the extent of variegation. The accessibility of multiple differentiated cell lineages in mice suggests that they may provide a tool for dissecting the role of chromatin‐mediated silencing in cell differentiation and tissue‐specific gene expression. (shrink)

Protein turnover (PT) has been formally defined only in equilibrium conditions, which is ill‐suited to quantify PT during dynamic processes that occur during embryogenesis or (extra) cellular signaling. In this Hypothesis, we propose a definition of PT in an out‐of‐equilibrium regime that allows the quantification of PT in virtually any biological context. We propose a simple mathematical and conceptual framework applicable to a broad range of available data, such as RNA sequencing coupled with pulsed‐SILAC datasets. We apply our framework to (...) a published dataset and show that stimulation of mouse dendritic cells with LPS leads to a proteome‐wide change in PT. This is the first quantification of PT out‐of‐equilibrium, paving the way for the analysis of biological systems in other contexts. (shrink)

The article sets the future of Christianity within the context of different master narratives, beginning with those employed by social scientists, scrutinizing some of their key characteristics. It then considers characteristics of master narratives in general, before looking at paradoxes of universalism and particularity, the collective and the individual, in relation to the inherent character of political reason.

Varios autores han realizado análisis sobre la relación entre la religión y la tecnología concluyendo diferentes interpretaciones, sin embargo el movimiento utópico transhumanista se presenta como un potencial desarrollo de nuestra empresa tecnocientífica que podría suponer una “superación” de la religión. En cambio atendiendo a la crítica que realizaron algunos pensadores al respecto, es posible observar una continuidad del proyecto transhumanista con ciertas corrientes herméticas y milenaristas. Para observar este fenómeno se investigan algunas de sus propuestas actuales y su posición (...) general sobre el fenómeno religioso, así como la opinión de la religión contemporánea (principalmente desde el cristianismo occidental) al respecto del transhumanismo. El artículo concluye con un intento de aportar consideraciones alternativas al respecto de la relación entre la religión y el desarrollo tecnológico. (shrink)

If we do not, at some point in our life, face death—thinking hard and straight about it—we turn away from our authenticity. If that facing rejects irrational faith, dogmas, mystification, and personal immortality, is there yet a path free of despair? David Martin argues that participatory pantheism—the experience of the secular and the sacred both as a unity and as a mystery—provides such a path.

Martin traces the genealogies of what he considers three of the most distinct and historically immediate fields of modern visual culture: the collection, the body, and the mapping of spaces.

Martin traces the genealogies of what he considers three of the most distinct and historically immediate fields of modern visual culture: the collection, the ...

We raise the new possibility that people diagnosed with developmental dyslexia (DD) are specialized in explorative cognitive search, and rather than having a neurocognitive disorder, play an essential role in human adaptation. Most DD research has studied educational difficulties, with theories framing differences in neurocognitive processes as deficits. However, people with DD are also often proposed to have certain strengths – particularly in realms like discovery, invention, and creativity – that deficit-centered theories cannot explain. We investigate whether these strengths reflect (...) an underlying explorative specialization. We re-examine experimental studies in psychology and neuroscience using the framework ofcognitive search, whereby many psychological processes involve a trade-off between exploration and exploitation. We report evidence of an explorative bias in DD-associated cognitive strategies. High DD prevalence and an attendant explorative bias across multiple areas of cognition suggest the existence of explorative specialization. An evolutionary perspective explains the combination of findings and challenges the view that individuals with DD have a disorder. In cooperating groups, individual specialization is favored when features that confer fitness benefits are functionally incompatible. Evidence for search specialization suggests that, as with some other social organisms, humans mediate the exploration–exploitation trade-off by specializing in complementary strategies. The existence of a system of collective cognitive search that emerges through collaboration would help to explain our species’ exceptional adaptiveness. It also aligns with evidence for substantial variability during our evolutionary history and the notion that humans are adapted not to a particular habitat but to variability itself. Specialization creates interdependence and necessitates balancing complementary strategies. Reframing DD therefore underscores the urgency of changing certain cultural practices to ensure we do not inhibit adaptation. Key improvements would remove cultural barriers to exploration and nurture explorative learning in education, academia, and the workplace, as well as emphasize collaboration over competition. Specialization in complementary search abilities represents a meta-adaptation; through collaboration, this likely enables human groups (as a species and as cultural systems) to successfully adapt. Cultural change to support this system of collaborative search may therefore be essential in confronting the challenges humanity now faces. (shrink)

There are ethical guidelines that form the foundation of the traditional doctor–patient relationship in medicine. Health care providers are under special obligations to their patients. These include obligations to disclose information, to propose alternative treatments that allow patients to make decisions based on their own values, and to have special concern for patients’ best interests. Furthermore, patients know that these obligations exist and so come to their physicians with a significant level of trust. In this sense, therapeutic medicine significantly differs (...) from straightforward business practices such as the buying and selling of houses, cars, cell phones, etc. However, we argue that this relationship differs when medicine is used for enhancement rather than therapy. When patients seek enhancements they are not as vulnerable as when they are ill. And in an enhancement setting, physicians have little role outside of medical risks to discuss motivation and alternatives. Therefore, we conclude that a more reasonable alternative may be for doctors and patients to use ethical norms associated more with straightforward business practices, specifically sales. We believe that full disclosure of this different set of norms will benefit both physicians and patients. (shrink)

Adrian Vermeule’s new vision of public law has whipped up a storm. It first aired on 31 March 2020, in his blogpost ‘Beyond Originalism’, under the rubric ‘common-good constitutionalism’.1 Within a...

Drosophila melanogaster is often considered to lack genomic 5‐methylcytosine (m5C), an opinion reinforced by two whole genome bisulfite‐sequencing studies that failed to find m5C. New evidence, however, indicates that genomic methylation is indeed present in the fly, albeit in small quantities and in unusual patterns. At embryonic stage 5, m5C occurs in short strand‐specific regions that cover ∼1% of the genome, at tissue levels suggesting a distribution restricted to a subset of nuclei. Its function is not obvious, but methylation in (...) subsets of nuclei would obscure functional associations since transcript levels and epigenetic modifications are assayed in whole embryos. Surprisingly, Mt2, the fly's only candidate DNA methyltransferase, is not necessary for the observed methylation. Full evaluation of the functions of genome methylation in Drosophila must await discovery and experimental inactivation of the DNA methyltransferase, as well as a better understanding of the pattern and developmental regulation of genomic m5C. (shrink)

Early reactions to the publication of Harold Garfinkel's Studies in Ethnomethodology, which have persisted over the passing decades, was that ethnomethodology could not address what sociology deemed to be socially significant matters such as 'power' and 'the state'. This, however, is not the case. How such matters enter into the practical everyday affairs of members is of equal interest to ethnomethodology when compared to how any matter enters into members' everyday life, and how they display that. It just does not (...) have more importance. Egon Bittner spelt this out with regard to Weber's interest in bureaucracy when he reminds sociology that when Weber talked about efficiency he was not referring to an objective standard but as something that is attuned to practical interests as they emerge in the context of everyday life. This paper examines some of the actions and interactions that were encountered in a Governmental Department in one of the European countries. It makes visible how characterisations of bureaucracy such as 'rational', and 'efficient' are achieved in the actions and interactions of Department employees, and some of the practices involved in that achievement. Garfinkel, and ethnomethodology in general, are not, in principle, to be found wanting where matters of overarching, primordial interest to sociology are concerned. (shrink)